This project provided the strategic recommendations on the requirements to obtain REACH registration number based on the conclusions for relevant environmental protection regulations. Communication platforms were engaged with the European Chemicals Agency and the Organization of Economic Cooperation and Development. Access to the information on the EU REACH and chemical substances’ information dissemination were provided to the local industries in order to encourage safe use and management of chemical substances. Recommended alternative methods to obtain EU REACH registration number were provided in the report. Based on the Toxic Chemicals Substances Control Act (TCSCA) of Taiwan’s Environmental Protection Administration, Executive Yuan, the discrepancies between the mechanisms of Taiwan’s TCSCA and the EU REACH Regulations were addressed and analyzed in this report. The recommendations of regulation amendment strategies were provided. The core values of the EU REACH were suggested to be adopted in Taiwan’s TCSCA by incorporating the existing chemical substances and new chemical substances’ registration mechanism into the current system in order to improve the current toxic substances’ screening mechanism. In this project, suggestions on chemical substances registration data requirements were proposed and analyzed. Planning of existing chemicals inventory database establishment and management strategies are completed. Plans for Taiwan’s new chemical substances notification management and operation mechanisms of relevant technical supporting units to conduct relevant work are completed. This project also referenced the evaluation and operation mechanisms of the substances of very high concern (SVHCs) in other countries and provided the recommendations for amendment of the TCSCA.