This project investigated the concentration of pharmaceuticals and personal care products (PPCPs) in the surface water and the wastewater of domestic hospitals and public sewage treatment plant. Based on the domestic use situation, toxicological data, risk quotient and foreign control status, this project proposed a list of 9 localized hospital wastewater management recommendations, and developed the management strategy for pharmaceutical wastewater. Besides, this project summarized both domestic and foreign persistent organic pollutants (POPs) management and the industrial usage in Taiwan, investigated perfluorinated compound and hexachlorobutadiene concentration of industrial wastewater, and drafted suggestion to the relevant control strategy. This project analyzed 22 water samples and 19 water samples for the investigation of perfluorinated compound and hexachlorobutadiene, respectively. The result showed that the concentration of nine perfluorinated compounds ranged from 0.399 to 1,540 μg/L and no hexachlorobutadiene was detected. To ensure the quality of river water bodies, this project conducted surveys on ammonia nitrogen, heavy metals, dioxin, and total mercury in coal-fired power plants to control and assess the pollution risk. The result showed that the concentration of nitrate nitrogen in a plant’s effluent water exceeded the Effluent Standards. Therefore, this project hold pollution improvement consultation meetings to assist the factory in reducing pollution and improving the quality of discharged water. Moreover, this project concluded the history information of the regulated items in the Effluent Standards, and developed the color information of industrial wastewater samples.